Purkinje cells in the cerebellum are among the largest neurons in the brain and have been extensively investigated in rodents. However, their morphological and physiological properties remain poorly understood in humans. In this study, we utilized high-resolution morphological reconstructions and unique electrophysiological recordings of human Purkinje cells ex vivo to generate computational models and estimate computational capacity.

Read more Masoli S, Sanchez-Ponce D, Vrieler N, Abu-Haya K, Lerner V, Shahar T, Nedelescu H, Rizza MF, Benavides-Piccione R, DeFelipe J, Yarom Y, Munoz A, D’Angelo E. Human Purkinje cells outperform mouse Purkinje cells in dendritic complexity and computational capacity. Commun Biol. 2024 Jan 2;7(1):5. doi: 10.1038/s42003-023-05689-y. PMID: 38168772; PMCID: PMC10761885.